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KMID : 1377020140110060483
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Tissue Engineering and Regenerative Medicine
2014 Volume.11 No. 6 p.483 ~ p.491
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Substance-p-mobilized mesenchymal stem cells accelerate skin wound healing
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Hong Hyun-Sook
Son Young-Sook
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Abstract
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Mesenchymal stem cells (MSCs) exert their therapeutic effects through differentiation into a variety of terminally differentiated cells or the release of paracrine factors. As a source for obtaining MSC, bone marrow has been used chiefly but the exploit of adipose tissue, dental pulp and peripheral blood is also increasing. Previous reports demonstrated that SP mobilizes bone marrow MSC to the circulation to be engaged in tissue repair. SP-mobilized MSC (MSCSP) could be expanded to show the colony forming efficiency and multi-differentiation potential, suggesting the possibility of MSCSP as cellular therapeutics. In this study, we have examined the efficacy of MSCSP in skin wound. MSCSP were topically transplanted to the wound and then, the regeneration was explored in time course. Contrary to vehicle treatment, MSCSP transplantation remarkably reduced the wound size and promoted both of epithelial migration and the recovery of granulation tissue within 7 days after transplantation. Moreover, MSCSPtreated mice showed the increased angiogenesis to make a broadly stretched vessel network. Although it were reported that the transplanted MSCs participated in tissue repair through differentiation, MSCSP was indeed not incorporated into skin cells and localized in dermis layer. As time passes, transplanted MSCSP disappeared rapidly, indicating that MSCSP-induced accelerated healing might be owing to paracrine factors. Collectively, our study revealed that MSCSP can promote skin wound healing, possibly by supplying cytokine and growth factor relating to tissue regeneration. Our results propose MSCSP as a potential therapeutic for inflammatory diseases in addition to cutaneous wound.
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KEYWORD
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Substance-p, mesenchymal stem cell, skin wound, angiogenesis
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